A 60-year-old woman presented after a fall and was noted to have ascites. She had a history of ulcerative colitis. History and physical examination did not reveal the likely aetiology of the ascites, but a sample showed it to be a blood-stained exudate. A malignant cause appeared likely, cross-sectional imaging was arranged and tumour markers sent. CA125 was 34 IU/ml (0-30); α-fetoprotein (AFP) and carcinoembryonic antigen (CEA) were normal. However, CA19-9 was 2880 U/ml (0-31). Pancreatic carcinoma or cholangiocarcinoma were of prime concern, but a CT scan and MRI imaging were normal. At laparoscopy a benign ruptured ovarian cyst was detected, and ascites drained. CA19-9 returned to normal and the patient remains well 9 months later. This case demonstrates how tumour markers may be misleading in the context of diagnostics, and is the highest reported example of CA19-9 rise in the context of benign ascites and benign ovarian pathology.
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机译：一名60岁女性在摔倒后出现并被发现患有腹水。她有溃疡性结肠炎病史。病史和体格检查未发现可能的腹水病因，但样本显示其为血染渗出液。可能出现恶性原因，安排了断层显像并发送了肿瘤标志物。 CA125为34 IU / ml（0-30）；甲胎蛋白（AFP）和癌胚抗原（CEA）正常。但是，CA19-9为2880 U / ml（0-31）。胰腺癌或胆管癌是最主要的问题，但CT扫描和MRI成像正常。腹腔镜检查发现良性卵巢囊肿破裂，腹水排出。 CA19-9恢复正常，患者9个月后恢复健康。该病例证明了肿瘤标志物在诊断方面可能会产生误导，并且是在良性腹水和卵巢良性病理情况下CA19-9升高的最高报道实例。
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